Product Info Summary
SKU: | A01876 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-Histidine decarboxylase HDC Antibody
SKU/Catalog Number
A01876
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Histidine decarboxylase HDC Antibody catalog # A01876. Tested in ELISA, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Histidine decarboxylase HDC Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01876)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human HDC.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01876 is reactive to HDC in Human, Mouse, Rat
Applications
A01876 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
74.141kDa
Background of HDC
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
McKay M.J., Genomics 36:305-315(1996).
Sadano H., Biochem. Biophys. Res. Commun. 267:418-422(2000).
Nomura N., DNA Res. 1:223-229(1994).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
Validation Images & Assay Conditions
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Western blot analysis of lysate from K562 cells, using HDC Antibody.
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Immunohistochemical analysis of paraffin-embedded Human stomach. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
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Immunohistochemical analysis of paraffin-embedded Human stomach. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
Click image to see more details
Immunohistochemical analysis of paraffin-embedded Human stomach. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
Click image to see more details
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
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Western blot analysis of K562 cells using HDC Polyclonal Antibody. Secondary antibody was diluted at 1:20000
Protein Target Info & Infographic
Gene/Protein Information For HDC (Source: Uniprot.org, NCBI)
Gene Name
HDC
Full Name
Histidine decarboxylase
Weight
74.141kDa
Superfamily
group II decarboxylase family
Alternative Names
histidine decarboxylase; MGC163399 HDC histidine decarboxylase histidine decarboxylase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HDC, check out the HDC Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HDC: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Histidine decarboxylase HDC Antibody (A01876)
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No publications found for A01876
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Customer Reviews
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Customer Q&As
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