Anti-Homeobox protein ESX1 ESX1 Antibody

Product Name

Anti-Homeobox protein ESX1 ESX1 Antibody

View all ESX1 Antibodies

SKU/Catalog Number

A08735

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Homeobox protein ESX1 ESX1 Antibody (Catalog # A08735). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Storage & Handling

ESX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Homeobox protein ESX1 ESX1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08735)

Host

Rabbit

Contents

ESX1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

ESX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human ESX1. The immunogen is located within amino acids 140 - 190 of ESX1.

Reactive Species

A08735 is reactive to ESX1 in Human

Observed Molecular Weight

68 kDa

Calculated molecular weight

44.3 kDa

Background of ESX1

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A08735 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ESX1 antibody can be used for detection of ESX1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information ESX1

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