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Product Info Summary
| SKU: | A00963-4 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-IL-22 Antibody
SKU/Catalog Number
A00963-4
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IL-22 Antibody (Catalog # A00963-4). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
IL-22 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-IL-22 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00963-4)
Host
Rabbit
Contents
IL-22 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IL-22 antibody was raised against a 17 amino acid peptide near the center of human IL-22 . The immunogen is located within amino acids 90 - 140 of IL-22.
Cross-reactivity
IL-22 antibody is human, mouse, and rat reactive. Multiple isoforms of IL-22 are known to exist.
Reactive Species
A00963-4 is reactive to IL22 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
20.0 kDa
Background of IL22
Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00963-4 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IL-22 antibody can be used for detection of IL-22 by Western blot at 0.5 μg/ml. Antibody can also be used for Immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IL-22 in HeLa cell lysate with IL-22 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of IL-22 in HeLa cells with IL-22 antibody at 5 μg/mL.
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Immunofluorescence of IL-22 in HeLa cells with IL-22 antibody at 20 μg/mL.
Specific Publications For Anti-IL-22 Antibody (A00963-4)
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