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Product Info Summary
| SKU: | A08339 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Mouse |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-IL-31 Antibody
SKU/Catalog Number
A08339
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IL-31 Antibody (Catalog # A08339). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Mouse.
Storage & Handling
IL-31 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-IL-31 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08339)
Host
Rabbit
Contents
IL-31 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IL-31 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of mouse IL-31. The immunogen is located within amino acids 30 - 80 of IL-31.
Reactive Species
A08339 is reactive to IL31 in Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
18.1 kDa
Background of IL31
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08339 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IL-31 antibody can be used for the detection of IL-31 by Western blot at 2.5 - 10 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 μg/mL.
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Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 μg/mL.
Specific Publications For Anti-IL-31 Antibody (A08339)
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