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Product Info Summary
| SKU: | A06336 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-INPP4B Antibody
SKU/Catalog Number
A06336
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-INPP4B Antibody (Catalog # A06336). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
INPP4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-INPP4B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06336)
Host
Rabbit
Contents
INPP4B antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B. The immunogen is located within the last 50 amino acids of INPP4B.
Cross-reactivity
INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist; this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A.
Reactive Species
A06336 is reactive to INPP4B in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Background of INPP4B
Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06336 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
INPP4B antibody can be used for detection of INPP4B by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of INPP4B in 3T3 cell lysate with INPP4B antibody at 1 μg/ml.
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Immunocytochemistry of INPP4B in 3T3 cells with INPP4B antibody at 2.5 μg/ml.
Specific Publications For Anti-INPP4B Antibody (A06336)
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