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Product Info Summary
| SKU: | A05598-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-IRF2BP2 Antibody
SKU/Catalog Number
A05598-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IRF2BP2 Antibody (Catalog # A05598-1). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
IRF2BP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-IRF2BP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05598-1)
Host
Rabbit
Contents
IRF2BP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IRF2BP2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human IRF2BP2. The immunogen is located within amino acids 440 - 490 of IRF2BP2.
Cross-reactivity
At least two isoforms of IRF2BP2 are known to exist; this antibody will detect both. This antibody is predicted to not cross-react with any FOXD4 protein family members.
Reactive Species
A05598-1 is reactive to IRF2BP2 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
61.0 kDa
Background of IRF2BP2
IRF2BP2, like the related protein IRF2BP1, is a co-repressor that interacts specifically with the C-terminal repression domain of Interferon Regulatory Factor 2 (IRF2). IRF2BP2 is a direct target gene of p53 and is involved in cell survival during the p53 stress response, able to impede the p53-mediated transactivation of p21 and Bax. IRF2BP2 is also a co-factor of VGLL4 and is required to induce the expression of vascular endothelial growth factor A (VEGF-A) in muscle. It is normally found in the nucleus of skeletal muscle and cardiac cells, but can be found in the cytoplasm during skeletal muscle differentiation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05598-1 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IRF2BP2 antibody can be used for detection of IRF2BP2 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IRF2BP2 in HeLa cell lysate with IRF2BP2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide
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Immunocytochemistry of IRF2BP2 in A20 cells with IRF2BP2 antibody at 2.5 μg/mL.
Specific Publications For Anti-IRF2BP2 Antibody (A05598-1)
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