Anti-Kremen protein 1 KREMEN1 Antibody

Product Name

Anti-Kremen protein 1 KREMEN1 Antibody

View all KREMEN1 Antibodies

SKU/Catalog Number

A10759

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Kremen protein 1 KREMEN1 Antibody (Catalog # A10759). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

KREMEN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-Kremen protein 1 KREMEN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10759)

Host

Rabbit

Contents

KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1. The immunogen is located within the last 50 amino acids of KREMEN1.

Cross-reactivity

Three isoforms of KREMEN1 exists as a result of alternative splicing event.

Reactive Species

A10759 is reactive to KREMEN1 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

51.7 kDa

Background of KREMEN1

Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A10759 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information KREMEN1

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