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Product Info Summary
| SKU: | A08612 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-LASS5 CERS5 Antibody
SKU/Catalog Number
A08612
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LASS5 CERS5 Antibody (Catalog # A08612). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
LASS5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LASS5 CERS5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08612)
Host
Rabbit
Contents
LASS5 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LASS5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human LASS5. The immunogen is located within the last 50 amino acids of LASS5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.
Reactive Species
A08612 is reactive to Cers5 in Human, Mouse, Rat
Applications
A08612 is guaranteed for ELISA, IF, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
48.167kDa
Background of Lass5
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LASS5 antibody can be used for detection of LASS5 by Western blot at 1 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LASS5 in SK-N-SH lysate with LASS5 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
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Immunofluorescence of LASS5 in human brain tissue with LASS5 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Cers5 (Source: Uniprot.org, NCBI)
Gene Name
Cers5
Full Name
Ceramide synthase 5
Weight
48.167kDa
Alternative Names
CerS5; FLJ25304; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5 (S. cerevisiae); LAG1 longevity assurance homolog 5; MGC45411; Trh4 Cers5|2310081H14Rik, AU045339, AW544927, Cer, L, Lass5, Trh, Trh4|ceramide synthase 5|ceramide synthase 5|LAG1 homolog, ceramide synthase 5|LAG1 longevity assurance homolog 5|TRAM homolog 4|longevity assurance homolog 5|sphingosine N-acyltransferase CERS5|translocating chain-associating membrane protein homolog 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Cers5, check out the Cers5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Cers5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LASS5 CERS5 Antibody (A08612)
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No publications found for A08612
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