Anti-Lipocalin-1 LCN1 Antibody
Rabbit IgG polyclonal antibody for Lipocalin-1(LCN1) detection. Tested with WB, IHC-P in Human.
Anti-Lipocalin-1 LCN1 Antibody Info At A Glance
|Product Name||Anti-Lipocalin-1 LCN1 Antibody
See all Lipocalin-1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Lipocalin 1/LCN1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Lipocalin 1/LCN1 information: Molecular Weight: 19250 MW; Subcellular Localization: Secreted; Tissue Specificity: Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.|
|Cite This Product||Anti-Lipocalin-1 LCN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1659)|
|Similar Products From
|Anti-Lipocalin-1 LCN1 Antibody may replace the following items: sc 34680|sc 34682|sc 34684|sc 374620|sc 398984|sc 66943.|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human LCN1(110-124aa HVKDHYIFYCEGELH).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For LCN1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||3933|
|Species Of This Entry||Human|
|Alternative Names||Lipocalin-1|LCN1; lipocalin 1 (tear prealbumin); lipocalin 1-like 2; Lipocalin1; Lipocalin-1; MGC71975; PMFA; Tear lipocalin; Tear Prealbumin; TLC; TPVon Ebner gland protein; VEG protein; VEGP; VEGPlipocalin 1 (protein migrating faster than albumin, tear prealbumin)|
|Post Tranlational Modifications||Phosphorylation; Reduction; Cleavage; Oxidation|
|Gene Location||9q34.3, on Chromasome 9, gene sequence: NC_000009.12 (135521296..135526540)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For LCN1 (Source: Uniprot.org, NCBI)
|Protein Function||Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.|
|Tissue Specificity||Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.|
|Related Diseases||Malignant Neoplasms; Salivary Gland Diseases; Dry Eye Syndromes; Carcinoma; Adenocarcinoma; Autoimmune Diseases; Small Cell Carcinoma Of Lung; Malignant Neoplasm Of Lung; Carcinoma, Neuroendocrine; Sjogren's Syndrome; Infective Disorder; Lung Neoplasms; Corneal Diseases; Autoimmune Reaction; Large Cell Neuroendocrine Carcinoma; Neoplasms; Pituitary Diseases; Inflammation; Carcinoma, Large Cell; Malignant Squamous Cell Neoplasm|
|Related Pathways||Lipid Binding; Transport; Localization; Reflex; Excretion; Secretion; Cell Activation; Secretory Pathway; Cell Proliferation; Fertilization; Menopause; Taste Perception; Flight; Reverse Transcription; Sensitization; Translation; Coagulation; Cell Motility; Protein Folding; Regulated Secretory Pathway|
|Background||Lipocalin-1(LCN1), also known as PREALBUMIN, TEAR or VEGP, is a protein that in humans is encoded by the LCN1 gene. Lipocalin-1 is a member of the lipocalin family of small secretory proteins, which is mapped on 9q34.3. Lipocalin-1 is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. It may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. LCN1 inhibits the cysteine-protease papain in vitro, similar to cystatins. And LCN1 plays a role in the nonimmunologic defense and in the control of inflammatory processes in oral and ocular tissues. The investigations presented the first clear evidence that LCN1 is induced in infection or inflammation and supported the idea that this lipocalin functions as a physiologic protection factor of epithelia in vivo.|
|Scientific References||PMID: 7679926 by Blaeker M., et al. Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands.|
PMID: 1400345 by Redl B., et al. cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily.
Our Boster Quality Guarantee for Anti-Lipocalin-1 LCN1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti LCN1 (PA1659) at 0.5ug/ml
Lane 1: JURKAT Whole Cell Lysate at 40ug
Lane 2: COLO320 Whole Cell Lysate at 40ug
Lane 3: SCG Whole Cell Lysate at 40ug
Lane 4: HELA Whole Cell Lysate at 40ug
Predicted bind size: 19KD
Observed bind size: 19KD
IHC(P): Human Prostatic Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
Other Recommended Resources
Here are featured tools and databases that you might find useful.
Order Product (PA1659)
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet.See Details
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Download Free PDFs Now
Guaranteed product quality
We promise all of our products perform as described in datasheets.