Product Info Summary
SKU: | A08181-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-MaxiK Beta 2 (I186) KCNMB2 Antibody
SKU/Catalog Number
A08181-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-MaxiK Beta 2 (I186) KCNMB2 Antibody catalog # A08181-1. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-MaxiK Beta 2 (I186) KCNMB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08181-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human KCNMB2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A08181-1 is reactive to KCNMB2 in Human, Mouse, Rat
Applications
A08181-1 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
27.13kDa
Background of KCNMB2
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Wallner M., Proc. Natl. Acad. Sci. U.S.A. 96:4137-4142(1999).
Brenner R., J. Biol. Chem. 275:6453-6461(2000).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of KCNMB2 using Anti-MaxiK Beta 2 (I186) KCNMB2 Antibody (A08181-1).
Immunohistochemistry (IHC) analyzes of MaxiKβ2 (I186) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.For more protocol information of IHC
Click image to see more details
Figure 1. Western blotting validation for Anti-MaxiK Beta 2 (I186) KCNMB2 Antibody A08181-1
Western blot (WB) analysis of MaxiKβ2 (I186) pAb at 1:500 dilutionLane1:SK-OVCAR3 whole cell lysate(40ug)
Lane2:A2780 whole cell lysate(40ug)
Lane3:The Ovary tissue lysate of Rat(40ug)
Lane4:The Brain tissue lysate of Mouse(40ug)
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For KCNMB2 (Source: Uniprot.org, NCBI)
Gene Name
KCNMB2
Full Name
Calcium-activated potassium channel subunit beta-2
Weight
27.13kDa
Superfamily
KCNMB (TC 8.A.14.1) family
Alternative Names
BK channel subunit beta-2; BKbeta2; calcium-activated potassium channel subunit beta-2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; hbeta2; hbeta3; k(VCA)beta-2; large conductance calcium-activated potassium channel beta 2 subunit; large-conductance Ca2+-activated K+ channel beta2 subunit; Maxi K channel subunit beta-2; MaxiK channel beta 2 subunit; MGC22431; potassium large conductance calcium-activated channel, subfamily M, beta member2; slo-beta-2 KCNMB2 potassium calcium-activated channel subfamily M regulatory beta subunit 2 calcium-activated potassium channel subunit beta-2|BK channel beta subunit 2|BK channel subunit beta-2|MaxiK channel beta 2 subunit|MaxiK channel beta-subunit 2|big potassium channel beta subunit 2|charybdotoxin receptor subunit beta-2|hCG1646471|hbeta2|k(VCA)beta-2|large conductance calcium-activated potassium channel beta 2 subunit|large-conductance Ca2+-activated K+ channel beta2 subunit|potassium channel subfamily M regulatory beta subunit 2|potassium large conductance calcium-activated channel, subfamily M, beta member 2|slo-beta-2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KCNMB2, check out the KCNMB2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KCNMB2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-MaxiK Beta 2 (I186) KCNMB2 Antibody (A08181-1)
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No publications found for A08181-1
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