Anti-Met (c-Met) Antibody Picoband™

HGFR/c-MET antibody

Boster Bio Anti-Met (c-Met) Antibody Picoband™ catalog # PB9186. Tested in WB applications. This antibody reacts with Human, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: PB9186
Size: 100 μg/vial
Reactive Species: Human, Rat
Host: Rabbit
Application: WB

Product Name

Anti-Met (c-Met) Antibody Picoband™

View all HGFR/c-MET Antibodies

SKU/Catalog Number

PB9186

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Met (c-Met) Antibody Picoband™ catalog # PB9186. Tested in WB applications. This antibody reacts with Human, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Met (c-Met) Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9186)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human Met recombinant protein (Position: D208-S407). Human Met shares 90% and 91% amino acid (aa) sequences identity with mouse and rat Met, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9186 is reactive to MET in Human, Rat

Applications

PB9186 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

154 kDa

Calculated molecular weight

155.541kDa

Background of HGFR/c-MET

c-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. It is mapped to 7q31.2. The protein possesses tyrosine kinase activity. MET is a membrane receptor that is essential for embryonic development and wound healing. It induces several biological responses that collectively give rise to a program known as invasive growth. MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Rat, Human

Validation Images & Assay Conditions

Gene/Protein Information For MET (Source: Uniprot.org, NCBI)

Gene Name

MET

Full Name

Hepatocyte growth factor receptor

Weight

155.541kDa

Superfamily

protein kinase superfamily

Alternative Names

AUTS9; cMET; c-MET; EC 2.7.10; EC 2.7.10.1; hepatocyte growth factor receptor; HGF R; HGF receptor; HGF/SF receptor; HGFR; Met (c-Met); met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET; oncogene MET; Proto-oncogene c-Met; RCCP2; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met MET AUTS9, DFNB97, HGFR, RCCP2, c-Met MET proto-oncogene, receptor tyrosine kinase hepatocyte growth factor receptor|HGF receptor|HGF/SF receptor|SF receptor|proto-oncogene c-Met|scatter factor receptor|tyrosine-protein kinase Met

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on MET, check out the MET Infographic

MET infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for MET: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9186 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Bin Wt, Ma Lm, Xu Q, Shi Xl. World J Gastroenterol. 2012 Jan 28;18(4):309-22. Doi: 10.3748/Wjg.V18.I4.309. Embryonic Hepatocyte Transplantation For Hepatic Cirrhosis: Efficacy And Mechanism Of Action.

Chen X, Ding G, Gao Q, Sun J, Zhang Q, Du L, Qiu Z, Wang C, Zheng F, Sun B, Ni J, Feng Z, Zhu J. Plos One. 2013 May 13;8(5):E63093. Doi: 10.1371/Journal.Pone.0063093. Print 2013. A Human Anti-C-Met Fab Fragment Conjugated With Doxorubicin As Targe...

Chen D, Wang W, Guo W, Yu Q, Burnstock G, He C, Xiang Z, Zheng H. J Anat. 2011 Jun;218(6):643-51. Doi: 10.1111/J.1469-7580.2011.01364.X. Epub 2011 Mar 18. Expression Of P2Y(6) Receptors In The Developing Mouse Skeletal Muscle And After Injury And ...

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1 Customer Q&As for Anti-Met (c-Met) Antibody Picoband™

Question

We are currently using anti-Met (c-Met) antibody PB9186 for human tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, rat. Is it true that the antibody can work on bovine tissues as well?

Verified Customer

Verified customer

Asked: 2020-04-30

Answer

The anti-Met (c-Met) antibody (PB9186) has not been validated for cross reactivity specifically with bovine tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in bovine you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2020-04-30

Order DetailsPrice
PB9186

100μg

$370
PB9186-10ug

10μg sample (liquid)

$99
PB9186-Biotin

100 μg Biotin conjugated

$570
PB9186-Cy3

100 μg Cy3 conjugated

$570
PB9186-Dylight488

100 μg Dylight488 conjugated

$570
PB9186-Dylight550

100 μg Dylight550 conjugated

$570
PB9186-Dylight594

100 μg Dylight594 conjugated

$570
PB9186-FITC

100 μg FITC conjugated

$570
PB9186-HRP

100 μg HRP conjugated

$570
PB9186-APC

100 μg APC conjugated

$670
PB9186-PE

100 μg PE conjugated

$670
PB9186-carrier-free

Carrier Free

$370

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PB9186
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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