MET Antibodies

Hepatocyte growth factor receptor (MET)

Receptor tyrosine kinase that transduces signals from the extracellular matrix to the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.

Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that offers docking sites for downstream signaling molecules. After activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.

Gene Information

Human
Gene Name:	MET
Uniprot:	P08581
Entrez:	4233

Family

Belongs to:
protein kinase superfamily

Alternative Names

AUTS9; cMET; c-MET; EC 2.7.10; EC 2.7.10.1; hepatocyte growth factor receptor; HGF R; HGF receptor; HGF/SF receptor; HGFR; Met (c-Met); met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET; oncogene MET; Proto-oncogene c-Met; RCCP2; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met

Molecular Weight

Mass (kDA):
155.541 kDA

Genomic Context

Human
Location:	7q31.2
Sequence:	7; NC_000007.14 (116672196..116798386)

Tissue Specificity

Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977).

Subcellular Localizations

Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

Diseases

• Neoplasms
• Malignant Neoplasms
• Carcinoma
• Neoplasm Metastasis
• Cell Transformation, Neoplastic
• Cell Invasion
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Lung
• Lung Neoplasms
• Adenocarcinoma
• Non-small Cell Lung Carcinoma
• Brain Neoplasms

• Malignant Neoplasm Of Breast
• Neoplasm Invasiveness
• Diabetes Mellitus
• Mammary Neoplasms
• Glioma
• Diabetes Mellitus, Non-insulin-dependent
• Tumor Progression

Pathways

• Cell Proliferation
• Cell Growth
• Pathogenesis
• Angiogenesis
• Localization
• Transport
• Cell Migration
• Cell Motility
• Cell Cycle
• Secretion
• Invasive Growth
• Oncogenesis
• Methylation

• Regeneration
• Drug Resistance
• Rna Interference
• Cell Death
• Translation
• Epithelial To Mesenchymal Transition
• Cell Adhesion

PTMs

• Phosphorylation
• Methylation
• Cleavage
• Ubiquitination
• Glycosylation
• Reduction
• Oxidation
• Demethylation
• Dephosphorylation

• Acetylation
• Hydroxylation
• Nitration
• Myristoylation
• Farnesylation
• Deacetylation
• Sumoylation
• Carboxylation
• Prenylation

• Geranylgeranylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MET

Best Uses Of The MET Marker

If you're interested in learning more about Steven Boster, you can read about his background and career in this bio. This article should answer a lot of your questions. It's a good idea for admirers to know a bit about the background of the person they admire. It is also essential to know what motivates them. A good bio will include both positive and negative aspects. This article will examine both.

About Steven Boster

About Steven Boster, the MET Markers – Who are they? This article explains the history of Boster, the significance of MET Markers and the reason why scientists should consider applying. In the past, Boster has received product credits for his work, but these are no more available. Today, however, scientists from all over the world are eligible to apply for the MET Marker. Continue reading to find out more about the award and the Boster scientists.

Career

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