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Product Info Summary
| SKU: | A00261 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-NAK TBK1 Antibody
SKU/Catalog Number
A00261
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-NAK TBK1 Antibody (Catalog # A00261). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
NAK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-NAK TBK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00261)
Host
Rabbit
Contents
NAK Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
NAK antibody was raised against a synthetic peptide corresponding to 17 amino acids form near the carboxy terminus of human NAK/TBK1. The immunogen is located within the last 50 amino acids of NAK.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross response to IKKa, IKKb, IKKy, or IKKe.
Reactive Species
A00261 is reactive to TBK1 in Human, Mouse
Applications
A00261 is guaranteed for ELISA, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
83.642kDa
Background of TBK1
Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. Phosphorylation of I-kappaB by IκB kinase (IKK) complex leads to degradation of I-kappaB and activation of NF-κB. The IKK complex contains IKKα, IKKβ, and IKKγ. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-κB-activating kinase), and T2K. NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-κB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
NAK antibody can be used for detection of NAK/TBK1 by Western blot. An 84 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunocytochemistry of NAK in MOLT4 cells with NAK antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TBK1 (Source: Uniprot.org, NCBI)
Gene Name
TBK1
Full Name
Serine/threonine-protein kinase TBK1
Weight
83.642kDa
Superfamily
protein kinase superfamily
Alternative Names
EC 2.7.11; EC 2.7.11.1; FLJ11330; FTDALS4; NAK; NAK serine; NAK serine/threonine-protein kinase TBK 1; NAK; NAKserine/threonine-protein kinase TBK1; NF-kappa-B-activating kinase; NFKB-Activating Kinase; T2K; TANK; TANK binding kinase; TANK-binding kinase 1NF-kB-activating kinase; TBK 1; TBK1 TBK1 FTDALS4, IIAE8, NAK, T2K TANK binding kinase 1 serine/threonine-protein kinase TBK1|NF-kB-activating kinase|NF-kappa-B-activating kinase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TBK1, check out the TBK1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TBK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NAK TBK1 Antibody (A00261)
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No publications found for A00261
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