Anti-NEDL2 HECW2 Antibody (Internal)

NEDL2 antibody

Boster Bio Anti-NEDL2 HECW2 Antibody (Internal) catalog # A08779. Tested in ELISA, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A08779
Size: 100ul
Reactive Species: Human
Host: Rabbit
Application: ELISA, WB

Customers Who Bought This Also Bought

Product Name

Anti-NEDL2 HECW2 Antibody (Internal)

View all NEDL2 Antibodies

SKU/Catalog Number

A08779

Size

100ul

Form

Liquid

Description

Boster Bio Anti-NEDL2 HECW2 Antibody (Internal) catalog # A08779. Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-NEDL2 HECW2 Antibody (Internal) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08779)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human NEDL2

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A08779 is reactive to HECW2 in Human

Applications

A08779 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

175.769kDa

Background of NEDL2

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner By similarity. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

Ota T., Nat. Genet. 36:40-45(2004).
Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Boulon S., Mol. Cell 16:777-787(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Innovating Scientists Reward

If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.

Submit A Review

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
ELISA 1:10000

Validation Images & Assay Conditions

Gene/Protein Information For HECW2 (Source: Uniprot.org, NCBI)

Gene Name

HECW2

Full Name

E3 ubiquitin-protein ligase HECW2

Weight

175.769kDa

Alternative Names

C2 and WW domain-containing protein 2; DKFZp686M17164; EC 6.3.2; EC 6.3.2.-; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase 2 HECW2 NDHSAL, NEDL2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 E3 ubiquitin-protein ligase HECW2|HECT-type E3 ubiquitin transferase HECW2|NEDD4-like E3 ubiquitin-protein ligase 2|NEDD4-related E3 ubiquitin ligase NEDL2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on HECW2, check out the HECW2 Infographic

HECW2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for HECW2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

No publications found for A08779

*Do you have publications using this product? Share with us and receive a reward. Ask us for more details.

Have you used Anti-NEDL2 HECW2 Antibody (Internal)?

Submit a review and receive an Amazon gift card.

  • $25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
  • $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit A Review

Be the first to review Anti-NEDL2 HECW2 Antibody (Internal)

*The first user to submit a review for a product is eligible for Boster's Innovating Scientists Reward, which gives product credits. This is in addition to the gift card reward.

Have a question?

Find answers in Q&As, reviews.

Can't find your answer?

Submit your question

0 Customer Q&As for Anti-NEDL2 HECW2 Antibody (Internal)

Order DetailsPrice
A08779-100ul

100ul

$380

Free Secondary Antibody

Choose an option to show lead time.
Get A Quote
Eddy test
In stock
Order Product
A08779
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$380.00

Troubleshooting

troubleshooting-box-image

Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.

Download Free PDFs Now

Boster Guarantee

Guaranteed product quality

Guaranteed product quality

We promise all of our products perform as described in datasheets.