Product Info Summary
SKU: | A02818 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | IHC |
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Product info
Product Name
Anti-Nesprin-2 SYNE2 Antibody
SKU/Catalog Number
A02818
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Nesprin-2 SYNE2 Antibody catalog # A02818. Tested in IHC applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Nesprin-2 SYNE2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02818)
Host
Rabbit
Contents
Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human SYNE2 protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02818 is reactive to SYNE2 in Human, Mouse
Applications
A02818 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
796.442kDa
Background of Nesprin 2
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.
Jiang-Hong Man, Nucleic Acids Res., Nov 2006; 34: 5552 - 5566.
Amir Sonnenblick, Mol. Cell. Biol., Dec 2004; 24: 10584 - 10592.
Jianyin Long, PNAS, Jan 2004; 101: 99.
Hyun Duk Jang, J. Biol. Chem., Jun 2004; 279: 24873 - 24880.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC-p 1:50-300
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For SYNE2 (Source: Uniprot.org, NCBI)
Gene Name
SYNE2
Full Name
Nesprin-2
Weight
796.442kDa
Superfamily
nesprin family
Alternative Names
DKFZP434H2235; DKFZp686E01115; DKFZp686H1931; EDMD5; FLJ46790; KIAA1011FLJ11014; nesprin 2; Nesprin-2; NUAFLJ43727; NUANCEFLJ45710; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; polytrophin; Protein NUANCE; spectrin repeat containing, nuclear envelope 2; Synaptic nuclear envelope protein 2; synaptic nuclei expressed gene 2; SYNE-2; TROPH SYNE2 EDMD5, KASH2, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH spectrin repeat containing nuclear envelope protein 2 nesprin-2|KASH domain-containing protein 2|nesprin 2|nuclear envelope spectrin repeat protein 2|nucleus and actin connecting element protein|polytrophin|spectrin repeat containing, nuclear envelope 2|synaptic nuclear envelope protein 2|synaptic nuclei expressed gene 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SYNE2, check out the SYNE2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SYNE2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Nesprin-2 SYNE2 Antibody (A02818)
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No publications found for A02818
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