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Product Info Summary
| SKU: | PA1203 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody
View all Nicotinic Acetylcholine R alpha 1/CHRNA1 Antibodies
SKU/Catalog Number
PA1203
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody catalog # PA1203. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1203)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Nicotinic Acetylcholine Receptor alpha 1, identical to the related rat sequence, different from the related mouse sequence by one amino acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1203 is reactive to CHRNA1 in Human, Mouse, Rat
Applications
PA1203 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
69 kDa
Calculated molecular weight
54.546kDa
Background of Nicotinic Acetylcholine R alpha 1/CHRNA1
CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
Click image to see more details
Anti-Nicotinic Acetylcholine Receptor alpha 1 antibody, PA1203, Western blotting
WB: Rat Skeletal Muscle Tissue Lysate
Protein Target Info & Infographic
Gene/Protein Information For CHRNA1 (Source: Uniprot.org, NCBI)
Gene Name
CHRNA1
Full Name
Acetylcholine receptor subunit alpha
Weight
54.546kDa
Superfamily
ligand-gated ion channel (TC 1.A.9) family
Alternative Names
acetylcholine receptor subunit alpha; ACHRA; ACHRD; CHNRA; cholinergic receptor, nicotinic, alpha 1 (muscle); CHRNA; CHRNA1; CMS2A; FCCMS; nAChR alpha 1; nAchRa1; Nicotinic Acetylcholine R alpha 1 ; Nicotinic Acetylcholine Ra1 ; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1; nicotinic, alpha polypeptide 1 (muscle); SCCMS CHRNA1 ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS cholinergic receptor nicotinic alpha 1 subunit acetylcholine receptor subunit alpha|acetylcholine receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic alpha 1|cholinergic receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)|muscle nicotinic acetylcholine receptor|nicotinic acetylcholine receptor alpha subunit|nicotinic cholinergic receptor alpha 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CHRNA1, check out the CHRNA1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CHRNA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (PA1203)
Hello CJ!
PA1203 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Su Y,Ahn B,Macpherson PCD,Ranjit R,Claflin DR,Van Remmen H,Brooks SV.Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling.Free Radic Biol Med.2021 Feb 6:S0891-5
Species: Mouse
PA1203 usage in article: APP:WB, SAMPLE:LIVER,MUSCLE AND SPINAL CORD, DILUTION:1:1000
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody
Question
We are currently using anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody PA1203 for rat tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on goat tissues as well?
Verified Customer
Verified customer
Asked: 2017-05-23
Answer
The anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody (PA1203) has not been validated for cross reactivity specifically with goat tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2017-05-23
