Product Info Summary
SKU: | A03471 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-APC1 ANAPC1 Antibody
SKU/Catalog Number
A03471
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-APC1 ANAPC1 Antibody (Catalog # A03471). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.
Storage & Handling
APC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-APC1 ANAPC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03471)
Host
Rabbit
Contents
APC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
APC1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human APC1. The immunogen is located within amino acids 1810 - 1860 of APC1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03471 is reactive to Anapc1 in Human, Mouse
Applications
A03471 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
215.994kDa
Background of Apc1
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
APC1 antibody can be used for detection of APC1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of APC1 in SK-N-SH cell lysate with APC1 antibody at (A) 1 and (B) 2 μg/mL.
Click image to see more details
Immunohistochemistry of APC1 in human brain tissue with APC1 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Anapc1 (Source: Uniprot.org, NCBI)
Gene Name
Anapc1
Full Name
Anaphase-promoting complex subunit 1
Weight
215.994kDa
Superfamily
APC1 family
Alternative Names
anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); anaphase-promoting complex subunit 1; APC1Testis-specific gene 24 protein; Cyclosome subunit 1; Mitotic checkpoint regulator; TSG24MCPR Anapc1|2610021O03Rik, AI047775, AI853536, AW547281, Ap, Apc1, Mc, Mcpr, tsg2, tsg24|anaphase promoting complex subunit 1|anaphase-promoting complex subunit 1|cyclosome subunit 1|meiotic check point regulator|mitotic checkpoint regulator|testis-specific gene 24 protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Anapc1, check out the Anapc1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Anapc1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-APC1 ANAPC1 Antibody (A03471)
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No publications found for A03471
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