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Product Info Summary
| SKU: | A00485 |
|---|---|
| Size: | 100 ug |
| Reactive Species: | Human, Rat |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-Notch3 Antibody
SKU/Catalog Number
A00485
Size
100 ug
Form
Liquid
Description
Boster Bio Anti-Notch3 Antibody (Catalog# A00485). Tested in WB, IHC applications. This antibody reacts with Human, Rat.
Storage & Handling
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Notch3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00485)
Host
Rabbit
Contents
PBS, pH7.2, 0.09% NaN3
Clonality
Polyclonal
Clone Number
OKT3
Isotype
Rabbit IgG
Immunogen
Synthetic peptide representing the C terminal region of the human NOTCH homolog 3 (NOTCH1) protein.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00485 is reactive to NOTCH3 in Human, Rat
Applications
A00485 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
243.631kDa
Background of Notch-3
The alpha-beta heterodimeric T-cell antigen receptor binds antigen in association with major histocompatibility complex proteins on host cell surfaces. These 2 disulfide-linked glycoproteins, TCRA and TCRB are associated on T-cell surfaces with a complex of proteins called CD3 (formerly T3). Human CD3 consists of at least 4 proteins: gamma, delta, epsilon, and zeta. The CD3-gamma/CD3-delta gene pair is within 300 kb of the CD3-epsilon gene and therefore these genes form a tightly linked cluster on 11q23. The clustering may be significant in terms of their simultaneous activations during T-cell development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
User needs to optimize the dilution ratio for this antibody.
Validation Images & Assay Conditions
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Figure 1. Immunofluorescent staining data of NOTCH3 using Anti-Notch3 Antibody (A00485).
Notch3 staining of rat cerebellum (Bergmann glia-10 micron cryostat sections). Working dilution is 1:100-1:300. Stained tissue was mounted under i-Brite Plus mounting media.Protein Target Info & Infographic
Gene/Protein Information For NOTCH3 (Source: Uniprot.org, NCBI)
Gene Name
NOTCH3
Full Name
Neurogenic locus notch homolog protein 3
Weight
243.631kDa
Superfamily
NOTCH family
Alternative Names
CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3 NOTCH3 CADASIL, CADASIL1, CASIL, IMF2, LMNS notch receptor 3 neurogenic locus notch homolog protein 3|Notch homolog 3|notch 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NOTCH3, check out the NOTCH3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NOTCH3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Notch3 Antibody (A00485)
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No publications found for A00485
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Customer Reviews
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