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Anti-P-Cadherin-3 CDH3-Antibody

P-Cadherin antibody

Boster Bio Anti-P-Cadherin-3 CDH3-Antibody catalog # PA1363. Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: PA1363
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: IHC, ICC, WB

Product Name

Anti-P-Cadherin-3 CDH3-Antibody

View all P-Cadherin Antibodies

SKU/Catalog Number

PA1363

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-P-Cadherin-3 CDH3-Antibody catalog # PA1363. Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-P-Cadherin-3 CDH3-Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1363)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human P cadherin, different from the mouse and rat sequences by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1363 is reactive to CDH3 in Human

Applications

PA1363 is guaranteed for IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

120 kDa

Calculated molecular weight

91.418kDa

Background of P-Cadherin

Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunocytochemistry , 0.5-1μg/ml, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For CDH3 (Source: Uniprot.org, NCBI)

Gene Name

CDH3

Full Name

Cadherin-3

Weight

91.418kDa

Alternative Names

CAD3; cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental); Cadherin-3; CDH3; CDHP; CDHPcalcium-dependent adhesion protein, placental; HJMD; PCAD; PCadherin; P-Cadherin; PCADP-cadherin; Placental cadherin CDH3 CDHP, HJMD, PCAD cadherin 3 cadherin-3|cadherin 3, type 1, P-cadherin (placental)|calcium-dependent adhesion protein, placental

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CDH3, check out the CDH3 Infographic

CDH3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CDH3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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4 Customer Q&As for Anti-P-Cadherin-3 CDH3-Antibody

Question

Is this PA1363 anti-P cadherin/CDH3 antibody reactive to the isotypes of CDH3?

Verified Customer

Verified customer

Asked: 2020-02-03

Answer

The immunogen of PA1363 anti-P cadherin/CDH3 antibody is A synthetic peptide corresponding to a sequence in the middle region of human P cadherin(612-626aa QDTYDVHLSLSDHGN), different from the mouse and rat sequences by one amino acid. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2020-02-03

Question

I see that the anti-P cadherin/CDH3 antibody PA1363 works with ICC, what is the protocol used to produce the result images on the product page?

Verified Customer

Verified customer

Asked: 2019-12-24

Answer

You can find protocols for ICC on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]

Boster Scientific Support

Answered: 2019-12-24

Question

Will PA1363 anti-P cadherin/CDH3 antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2019-06-10

Answer

It shows on the product datasheet, PA1363 anti-P cadherin/CDH3 antibody as been tested on ICC. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2019-06-10

Question

We are currently using anti-P cadherin/CDH3 antibody PA1363 for human tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human. Is it likely that the antibody can work on zebrafish tissues as well?

S. Patel

Verified customer

Asked: 2019-05-02

Answer

The anti-P cadherin/CDH3 antibody (PA1363) has not been validated for cross reactivity specifically with zebrafish tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-05-02

Order DetailsPrice
PA1363

100μg

$370
PA1363-10ug

10μg sample (liquid)

$99
PA1363-Biotin

100 μg Biotin conjugated

$570
PA1363-Cy3

100 μg Cy3 conjugated

$570
PA1363-Dylight488

100 μg Dylight488 conjugated

$570
PA1363-Dylight550

100 μg Dylight550 conjugated

$570
PA1363-Dylight594

100 μg Dylight594 conjugated

$570
PA1363-FITC

100 μg FITC conjugated

$570
PA1363-HRP

100 μg HRP conjugated

$570
PA1363-APC

100 μg APC conjugated

$670
PA1363-PE

100 μg PE conjugated

$670
PA1363-carrier-free

Carrier Free

$370

More conjugates/formats

Free Secondary Antibody

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PA1363
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

Troubleshooting

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