Product Info Summary
SKU: | A03309 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-P2Y purinoceptor 1 P2RY1 Antibody
View all P2Y1/P2RY1 Antibodies
SKU/Catalog Number
A03309
Size
100ul
Form
Liquid
Description
Boster Bio Anti-P2Y purinoceptor 1 P2RY1 Antibody catalog # A03309. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-P2Y purinoceptor 1 P2RY1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03309)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human COLQ
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03309 is reactive to P2RY1 in Human, Mouse, Rat
Applications
A03309 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
42.072kDa
Background of P2Y1/P2RY1
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis, particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B.
Kawai T., Mol. Cell. Biol. 18:1642-1651(1998).
Murata-Hori M., FEBS Lett. 451:81-84(1999).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-P2Y purinoceptor 1 P2RY1 Antibody A03309
Western blot analysis of extracts of various cellsProtein Target Info & Infographic
Gene/Protein Information For P2RY1 (Source: Uniprot.org, NCBI)
Gene Name
P2RY1
Full Name
P2Y purinoceptor 1
Weight
42.072kDa
Superfamily
G-protein coupled receptor 1 family
Alternative Names
ATP receptor; P2 purinoceptor subtype Y1; P2RY1; P2Y purinoceptor 1; P2Y1; P2Y1platelet ADP receptor; purinergic receptor P2Y, G-protein coupled, 1; Purinergic receptor P2RY1 P2Y1, SARCC purinergic receptor P2Y1 P2Y purinoceptor 1|ADP receptor|ATP receptor|P2 purinoceptor subtype Y1|platelet ADP receptor|purinergic receptor P2Y, G-protein coupled, 1|suppressing androgen receptor in renal cell carcinoma
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on P2RY1, check out the P2RY1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for P2RY1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-P2Y purinoceptor 1 P2RY1 Antibody (A03309)
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