Anti-P5CS/ALDH18A1 Antibody Picoband™

ALDH18A1 antibody

Boster Bio Anti-P5CS/ALDH18A1 Antibody Picoband™ catalog # A06119-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A06119-2
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, Flow Cytometry, WB

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Product Name

Anti-P5CS/ALDH18A1 Antibody Picoband™

View all ALDH18A1 Antibodies

SKU/Catalog Number

A06119-2

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-P5CS/ALDH18A1 Antibody Picoband™ catalog # A06119-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-P5CS/ALDH18A1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06119-2)

Host

Rabbit

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human P5CS/ALDH18A1 recombinant protein (Position: M1-A224).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A06119-2 is reactive to ALDH18A1 in Human, Mouse, Rat

Applications

A06119-2 is guaranteed for ELISA, Flow Cytometry, WB Boster Guarantee

Observed Molecular Weight

87 kDa

Calculated molecular weight

87.302kDa

Background of ALDH18A1

Delta-1-pyrroline-5-carboxylate synthetase (P5CS) is an enzyme that in humans is encoded by the ALDH18A1 gene. This gene is mapped to 10q24.1. This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Flow Cytometry, 1-3μg/1x106 cells, Human
Direct ELISA, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For ALDH18A1 (Source: Uniprot.org, NCBI)

Gene Name

ALDH18A1

Full Name

Delta-1-pyrroline-5-carboxylate synthase

Weight

87.302kDa

Alternative Names

aldehyde dehydrogenase 18 family, member A1; Aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthase; EC 2.1.2.11; EC 2.3.3.13; GSASdelta1-pyrroline-5-carboxlate synthetase; MGC117316; P5CSdelta-1-pyrroline-5-carboxylate synthetase; PYCSEC 1.2.1.41; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase) ALDH18A1 ADCL3, ARCL3A, GSAS, P5CS, PYCS, SPG9, SPG9A, SPG9B aldehyde dehydrogenase 18 family member A1 delta-1-pyrroline-5-carboxylate synthase|Spastic paraplegia-9 (spastic paraparesis with amyotrophy, cataracts and gastroesophageal reflux)|aldehyde dehydrogenase family 18 member A1|delta-1-pyrroline-5-carboxylate synthetase|delta1-pyrroline-5-carboxlate synthetase|pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)|spastic paraplegia 9 (autosomal dominant)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ALDH18A1, check out the ALDH18A1 Infographic

ALDH18A1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ALDH18A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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1 Customer Q&As for Anti-P5CS/ALDH18A1 Antibody Picoband™

Question

We are currently using anti-P5CS/ALDH18A1 antibody A06119-2 for rat tissue, and we are satisfied with the ELISA results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on dog tissues as well?

Verified Customer

Verified customer

Asked: 2017-08-09

Answer

The anti-P5CS/ALDH18A1 antibody (A06119-2) has not been validated for cross reactivity specifically with dog tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in dog you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2017-08-09

Size

Conjugation

Total: $370

SKU:A06119-2

In stock, 3+ left.

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A06119-2
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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