Anti-Paxillin Pxn Antibody (Monoclonal, 35P89)

Anti-Paxillin Pxn Antibody (Monoclonal, 35P89)
View all PXN Antibodies

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3.

35P89

C-terminal part of recombinant chicken paxillin (amino acids 305-559).

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

The paxillin gene can be alternatively spliced to include 1 of 2 alternative exons, generating beta and gamma isoforms. Paxillin is a 68-kDa focal adhesion protein that is phosphorylated on tyrosine residues in fibroblasts in response to transformation by v-src, treatment with platelet-derived growth factor, or cross-linking of integrins. The 68-kD protein (paxillin) is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal adhesions of Madin-Darby bovine kidney (MDBK) epithelial cells but is absent, like talin, from the cell-cell adherens junctions of these cells.