Anti-Phospho-KOR-1 (S369) OPRK1 Antibody

Product Name

Anti-Phospho-KOR-1 (S369) OPRK1 Antibody

View all KOR Antibodies

SKU/Catalog Number

A02906S369-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Phospho-KOR-1 (S369) OPRK1 Antibody catalog # A02906S369-1. Tested in ELISA, IHC-P, WB applications. This antibody reacts with Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Phospho-KOR-1 (S369) OPRK1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02906S369-1)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human KOR-1 around the phosphorylation site of S369.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02906S369-1 is reactive to OPRK1 in Mouse, Rat

Applications

A02906S369-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

42.645kDa

Background of KOR

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Kajita Y., J. Biol. Chem. 270:22167-22175(1995).
Dempsey L.A., Genomics 49:378-384(1998).
Tolnay M., Biochem. J. 338:417-425(1999).
Grosset C., Cell 103:29-40(2000)

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000

Validation Images & Assay Conditions

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Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

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Western blot analysis of various cells using Phospho-KOR-1 (S369) Polyclonal Antibody diluted at 1:1000

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Western blot analysis of Rat-kidney cells using Phospho-KOR-1 (S369) Polyclonal Antibody diluted at 1:1000

Gene/Protein Information For OPRK1 (Source: Uniprot.org, NCBI)

Alternative Names

kappa opioid receptor; kappa-type opioid receptor; KOR; K-OR-1; KOR-1; Opiate receptor, kappa-1; opioid receptor, kappa 1; OPRK; OPRK1; Oprk2; R21 OPRK1 K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK opioid receptor kappa 1 kappa-type opioid receptor|Opiate receptor, kappa-1|kappa opioid receptor

For more info on OPRK1, check out the OPRK1 Infographic

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In this infographic, you will see the following information for OPRK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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