Anti-Phospho-PLC beta (S1105) PLCB3 Antibody

Product Name

Anti-Phospho-PLC beta (S1105) PLCB3 Antibody

View all PLC-beta 3 Antibodies

SKU/Catalog Number

A04226S1105

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Phospho-PLC beta (S1105) PLCB3 Antibody catalog # A04226S1105. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Phospho-PLC beta (S1105) PLCB3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04226S1105)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human PLC beta3 around the phosphorylation site of S1105. At AA range: 1040-1120

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04226S1105 is reactive to PLCB3 in Human, Mouse, Rat

Applications

A04226S1105 is guaranteed for ELISA, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

138.799kDa

Background of PLC-beta 3

Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

Toyoshima H., Proc. Natl. Acad. Sci. U.S.A. 90:5404-5408(1993).
Krolewski J.J., EMBO J. 10:2911-2919(1991).
Maru Y., Oncogene Res. 5:199-204(1990).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-Phospho-PLC beta (S1105) PLCB3 Antibody A04226S1105

Western Blot (WB) analysis of specific cells using Phospho-PLC beta3 (S1105) polyclonal antibody.

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Figure 2. Immunohistochemistry validation of PLCB3 using Anti-Phospho-PLC beta (S1105) PLCB3 Antibody (A04226S1105).

Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100 (4°C, overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antibody retrieval. Negative control (right) obtained from antibody was pre-absorbed by immunogen peptide.

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Figure 3. Immunohistochemistry validation of PLCB3 using Anti-Phospho-PLC beta (S1105) PLCB3 Antibody (A04226S1105).

Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100 (4°C, overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antibody retrieval. Negative control (right) obtained from antibody was pre-absorbed by immunogen peptide.

Gene/Protein Information For PLCB3 (Source: Uniprot.org, NCBI)

Alternative Names

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; EC 3.1.4.11; FLJ37084; Phosphoinositide phospholipase C-beta-3; phospholipase C, beta 3 (phosphatidylinositol-specific); Phospholipase C-beta-3; PLC beta 3; PLCB3; PLCbeta 3; PLC-beta 3; PLC-beta-3 PLCB3 SMDCD phospholipase C beta 3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3|PLC beta 3|phosphoinositide phospholipase C-beta-3|phospholipase C, beta 3 (phosphatidylinositol-specific)

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