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- Table of Contents
Presenilin-2 Antibodies
AND PSEN2 ELISA kits, Presenilin-2 Proteins
Many biological assays use antibodies to detect Presenilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Presenilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Presenilin-2 antibodies...
Designing a Western blot for Presenilin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PSEN2 Western Blot GuidePSEN2 Infographic by Boster Bio
All PSEN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00800
100 μg/vial
Cat # A00800
100 μg/vial
Human, Mouse
ELISA
$540
Cat # EKC2283
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2283
1 kit, containing two 96-well plates and all necessary reagents
PSEN2 Overview
Facts about Presenilin-2.
Presenilin-2 (PSEN2)
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of this gamma-secretase complex to have a protease activity.
May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSEN2 |
| Uniprot: | P49810 |
| Entrez: | 5664 |
Family
| Belongs to: |
|---|
| peptidase A22A family |
Alternative Names
AD3LP; AD4AD3L; AD5; E5-1; EC 3.4.23; EC 3.4.23.-; presenilin 2 (Alzheimer disease 4); Presenilin2; Presenilin-2; PS-2; PS2CMD1V; PSEN2; PSNL2; STM2STM-2
Molecular Weight
Mass (kDA):
50.14 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q42.13 |
| Sequence: | 1; NC_000001.11 (226870572..226903829) |
Tissue Specificity
Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Diseases
- Alzheimer's Disease
- Alzheimer Disease, Familial
- Dementia
- Neurodegenerative Disorders
- Neurofibrillary Tangles
- Plaque, Amyloid
- Senile Plaques
- Nerve Degeneration
- Malignant Neoplasms
- Neuroblastoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Impaired Cognition
Interacting Proteins
- DYNC1H1
- ECSIT
- PDCD4
Pathways
- Pathogenesis
- Proteolysis
- Cell Death
- Localization
- Secretion
- Transport
- Aging
- Programmed Cell Death
- Cell Proliferation
- Protein Processing
- Cell Cycle
- Rna Interference
- Translation
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Gamma-cleavage
- Methylation
- Biotinylation
- Dephosphorylation
Research Areas
- Alzheimers Research
- Apoptosis
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSEN2
bosterbio.com/bosterbio-gene-info-cards/PSEN2
References
PMID: 7638622 by Levy-Lahad E., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus.
PMID: 7651536 by Rogaev E.I., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.