Anti-Presenilin 2/PSEN2 Antibody
Rabbit IgG polyclonal antibody for Presenilin-2(PSEN2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Presenilin 2/PSEN2 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
Your ideal low cost ELISA solution. EZ Set™ ELISA kit contains the necessary core reagents develop and run the ELISA, including ELISA-optimized matched antibody pairs, recombinant protein standards, and HRP conjugated Avidin-Biotin-Complex (ABC). One kit is sufficient for developing 5 plates (96 well format). EZ Set™ ELISAs are ideal for experienced ELISA users on a budget and great for exploratory work--a fast and easy way to identify the relevant protein targets of interest/relevance to your studies.
Boster also provides the most comprehensive technical support materials and most user friendly technical support service to guarantee that you can do the experiment smoothly and successfully.
|Product Name||Anti-Presenilin 2/PSEN2 Antibody
See all Presenilin-2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Presenilin 2/PSEN2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Presenilin 2/PSEN2 information: Molecular Weight: 50140 MW; Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein ; Tissue Specificity: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.|
|Cite This Product||Anti-Presenilin 2/PSEN2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1358)|
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|Anti-Presenilin 2/PSEN2 Antibody may replace the following items: sc 1456|sc 1456 R|sc 1457|sc 393758|sc 7861.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human Presenilin 2(39-51aa EDGENTAQWRSQE), different from the related mouse and rat sequences by two amino acids.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For PSEN2 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||5664|
|Species Of This Entry||Human|
|Superfamily||peptidase A22A family|
|Alternative Names||Presenilin-2|AD3LP; AD4AD3L; AD5; E5-1; EC 3.4.23; EC 3.4.23.-; presenilin 2 (Alzheimer disease 4); Presenilin2; Presenilin-2; PS-2; PS2CMD1V; PSEN2; PSNL2; STM2STM-2|
|Post Tranlational Modifications||Cleavage; Phosphorylation; Glycosylation; Gamma-cleavage; Methylation; Biotinylation; Dephosphorylation; Ubiquitination; Palmitoylation; Myristoylation; Demethylation; Citrullination; Reduction; Acetylation|
|Subcellular Localization||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.|
|Gene Location||1q42.13, on Chromasome 1, gene sequence: NC_000001.11 (226870572..226903829)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For PSEN2 (Source: Uniprot.org, NCBI)
|Protein Function||Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.|
|Tissue Specificity||Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.|
|Interacting Proteins||DYNC1H1; ECSIT; PDCD4|
|Research Areas||Alzheimers Research; Apoptosis; Neuroscience|
|Related Diseases||Alzheimer's Disease; Alzheimer Disease, Familial; Dementia; Neurodegenerative Disorders; Neurofibrillary Tangles; Plaque, Amyloid; Senile Plaques; Nerve Degeneration; Malignant Neoplasms; Neuroblastoma; Malignant Neoplasm Of Breast; Mammary Neoplasms; Impaired Cognition; Neoplasms; Frontotemporal Dementia; Nervousness; Neuropathology Disease; Parkinson Disease; Memory Impairment; Carcinoma|
|Related Pathways||Pathogenesis; Proteolysis; Cell Death; Localization; Secretion; Transport; Aging; Programmed Cell Death; Cell Proliferation; Protein Processing; Cell Cycle; Rna Interference; Translation; Methylation; Cell Growth; Cell Adhesion; Embryo Development; Somitogenesis; Glycosylation; Mitosis|
|Background||Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al.(1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments(endoplasmic reticulum and Golgi complex). Li et al.(1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.|
|Scientific References||PMID: 7638622 by Levy-Lahad E., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus.|
PMID: 7651536 by Rogaev E.I., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.
Our Boster Quality Guarantee for Anti-Presenilin 2/PSEN2 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Rat Brain Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: MCF-7 Cell Lysate
Lane 4: HELA Cell Lysate
Lane 5: SMMC Cell Lysate
Lane 6: CEM Cell Lysate
IHC(P): Human Mammary Cancer Tissue
IHC(P): Rat Cardiac Muscle Tissue
IHC(P): Rat Kidney Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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