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Product Info Summary
| SKU: | A02221 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-PHOX2B Antibody
SKU/Catalog Number
A02221
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PHOX2B Antibody (Catalog # A02221). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PHOX2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PHOX2B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02221)
Host
Rabbit
Contents
PHOX2B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B. The immunogen is located within amino acids 130 - 180 of PHOX2B.
Cross-reactivity
PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.
Reactive Species
A02221 is reactive to PHOX2B in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
31.6 kDa
Background of PHOX2B
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02221 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PHOX2B antibody can be used for detection of PHOX2B by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PHOX2B in 293 cell lysate with PHOX2B antibody at (A) 1 and (B) 2 μg/mL.
Specific Publications For Anti-PHOX2B Antibody (A02221)
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