PHOX2B Antibodies

AND PHOX2B ELISA kits, PHOX2B Proteins

Many biological assays use antibodies to detect PHOX2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHOX2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHOX2B antibodies...

We validate the specificity of these antibodies to PHOX2B by testing them on tissues known to express PHOX2B positively and negatively. Browse below to find the PHOX2B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for PHOX2B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the PHOX2B Western Blot Guide

PHOX2B Infographic by Boster Bio

All PHOX2B Products

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Product

Figures

Specificity

Applications

Price

Anti-PHOX2B Monoclonal Antibody

Western blot analysis of PHOX2B expression in Neuro-2a cell lysate

Human, Mouse

IF, IHC, ICC, WB

$370
Cat # M02221
100 μl

PHOX2B (NM_003924) Human Over-expression Lysate

Human

$628
Cat # LS008929
20 µg, 100 µg

Anti-PHOX2B Antibody

Western blot analysis of PHOX2B in 293 cell lysate with PHOX2B antibody at (A) 1 and (B) 2 μg/mL

Human, Mouse, Rat

ELISA, WB

$481
Cat # A02221
0.1 mg

PHOX2B Overview

Facts about Paired mesoderm homeobox protein 2B.

PHOX2B 3D structure. Source: alphafold

Paired mesoderm homeobox protein 2B (PHOX2B)

Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates.

Improves second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response component and serum- response element. .

Gene Information

Human
Gene Name:	PHOX2B
Uniprot:	Q99453
Entrez:	8929

Family

Belongs to:

paired homeobox family

Alternative Names

NBPhox; NBPhoxPhox2b; Neuroblastoma Phox; paired mesoderm homeobox 2b; paired mesoderm homeobox protein 2B; paired-like homeobox 2bNBLST2; PHOX2B homeodomain protein; PHOX2B; PMX2B; PMX2Bneuroblastoma paired-type homeobox protein

Molecular Weight

Mass (kDA):
31.621 kDA

Genomic Context


Human

Location:	4p13
Sequence:	4; NC_000004.12 (41744082..41748725, complement)

Tissue Specificity

Expressed in neuroblastoma, brain and adrenal gland.

Subcellular Localizations

Nucleus.

Diseases

Hypoventilation
Congenital Central Hypoventilation
Nervousness
Crest Syndrome
Sleep Apnea, Central
Neuroblastoma
Hirschsprung Disease
Neoplasms
Hypercapnia
Hypoxia
Disease Of Adrenal Medulla
Autonomic Nervous System Disorders

Apnea
Sleep-related Respiratory Failure
Embryonic Mosaic
Malignant Neoplasms
Neoplasm, Residual
Mutation, Out-of-frame

Pathways

Neurogenesis
Pathogenesis
Reflex
System Development
Neuron Development
Neuron Differentiation
Nervous System Development
Innervation
Cell Differentiation
Cell Development
Autophagy
Cell Proliferation
Autonomic Nervous System Development

Response To Hypoxia
Methylation
Cell Migration
Cell Cycle
Localization
Secretion
Cell Adhesion

PTMs

Methylation
Phosphorylation

Biotinylation
Cleavage

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHOX2B

References

PMID: 9039501 by Yokoyama M., et al. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles.

PMID: 11034547 by Adachi M., et al. Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta- hydroxylase gene transcription.