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Product Info Summary
| SKU: | A17906 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-PIERCE1 C9orf116 Antibody
SKU/Catalog Number
A17906
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PIERCE1 C9orf116 Antibody (Catalog # A17906). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
PIERCE1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PIERCE1 C9orf116 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A17906)
Host
Rabbit
Contents
PIERCE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PIERCE1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human PIERCE1. The immunogen is located within the first 50 amino acids of PIERCE1.
Cross-reactivity
PIERCE1 antibody is predicted to not cross-react with other UPF0691 family members.
Reactive Species
A17906 is reactive to C9ORF116 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
15.3 kDa
Background of C9ORF116
PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A17906 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PIERCE1 antibody can be used for detection of PIERCE1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PIERCE1 in A20 cell lysate with PIERCE1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunocytochemistry of PIERCE1 in A20 cells with PIERCE1 antibody at 2.5 μg/mL.
Specific Publications For Anti-PIERCE1 C9orf116 Antibody (A17906)
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