Anti-PTCHD2 DISP3 Antibody

Product Name

Anti-PTCHD2 DISP3 Antibody

View all PTCHD2 Antibodies

SKU/Catalog Number

A11929-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-PTCHD2 DISP3 Antibody (Catalog # A11929-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

PTCHD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-PTCHD2 DISP3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11929-1)

Host

Rabbit

Contents

PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

PTCHD2 antibody was raised against a 19 amino acid synthetic peptide from near the center of human PTCHD2. The immunogen is located within amino acids 780 - 830 of PTCHD2.

Cross-reactivity

At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins.

Reactive Species

A11929-1 is reactive to PTCHD2 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

153.0 kDa

Background of PTCHD2

PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A11929-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Recommend Dilution

PTCHD2 antibody can be used for detection of EPAC1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information PTCHD2

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