Product Info Summary
SKU: | A06984 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-RGM domain family member B RGMB Antibody
SKU/Catalog Number
A06984
Size
100ul
Form
Liquid
Description
Boster Bio Anti-RGM domain family member B RGMB Antibody catalog # A06984. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-RGM domain family member B RGMB Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06984)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
A synthetic peptide corresponding to residues in Human RGMB
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A06984 is reactive to Rgmb in Human, Mouse, Rat
Applications
A06984 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
47.181kDa
Background of RGM-B
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Celeste A.J., Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W., Nature 434:724-731(2005).
Mazerbourg S., J. Biol. Chem. 280:32122-32132(2005).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
Validation Images & Assay Conditions
Click image to see more details
Western blot (WB) analysis of RGMB polyclonal antibody at 1:500 dilution
Lane1:HEK293T whole cell lysate
Lane2:NIH-3T3 whole cell lysate
Lane3:H9C2 whole cell lysate
Protein Target Info & Infographic
Gene/Protein Information For Rgmb (Source: Uniprot.org, NCBI)
Gene Name
Rgmb
Full Name
RGM domain family member B
Weight
47.181kDa
Superfamily
repulsive guidance molecule (RGM) family
Alternative Names
DKFZp434P228; Dragon; DRG11-responsive axonal guidance and outgrowth of neurite; RGM domain family, member B; RGMB; RGM-B Rgmb|1110059F19Rik, DR, DRAGON|repulsive guidance molecule family member B|RGM domain family member B|DRG11-responsive axonal guidance and outgrowth of neurite|RGM domain family, member B|repulsive guidance molecule B
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Rgmb, check out the Rgmb Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Rgmb: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-RGM domain family member B RGMB Antibody (A06984)
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No publications found for A06984
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