Click image to see more details
Product Info Summary
| SKU: | M12849 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, ICC, WB |
Customers Who Bought This Also Bought
Product info
Product Name
Anti-SCIMP Purified Monoclonal Antibody
SKU/Catalog Number
M12849
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SCIMP Purified Monoclonal Antibody (Catalog# M12849). Tested in Flow Cytometry, IP, WB, ICC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-SCIMP Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M12849)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
NVL-07
Isotype
Mouse IgG2a
Immunogen
Recombinant intracellular part of human SCIMP. The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Reactive Species
M12849 is reactive to Scimp in Human
Applications
M12849 is guaranteed for Flow Cytometry, IP, ICC, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
17.14kDa
Background of Scimp
SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
Submit A Review
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: Intracellular staining.
Western blotting: 1-2 μg/ml.
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Flow Cytometry validation of SCIMP using Anti-SCIMP Purified Monoclonal Antibody (M12849).
Flow cytometry analysis (intracellular staining) of SCIMP in a population of HEK-293T-SCIMP transfectants using monoclonal antibody (clone NVL-07Protein Target Info & Infographic
Gene/Protein Information For Scimp (Source: Uniprot.org, NCBI)
Gene Name
Scimp
Full Name
SLP adapter and CSK-interacting membrane protein
Weight
17.14kDa
Alternative Names
transmembrane protein C17orf87; C17orf87; chromosome 17 open reading frame 87; DTFT5783; FLJ32580; SLP adapter and CSK-interacting membrane protein; SLP adaptor and CSK interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein; UNQ5783
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Scimp, check out the Scimp Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Scimp: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SCIMP Purified Monoclonal Antibody (M12849)
Hello CJ!
No publications found for M12849
*Do you have publications using this product? Share with us and receive a reward. Ask us for more details.
Recommended Resources
Here are featured tools and databases that you might find useful.
- Boster's Pathways Library
- Protein Databases
- Bioscience Research Protocol Resources
- Data Processing & Analysis Software
- Photo Editing Software
- Scientific Literature Resources
- Research Paper Management Tools
- Molecular Biology Software
- Primer Design Tools
- Bioinformatics Tools
- Phylogenetic Tree Analysis
Customer Reviews
Have you used Anti-SCIMP Purified Monoclonal Antibody?
Submit a review and receive an Amazon gift card.
- $30 for a review with an image
Be the first to review Anti-SCIMP Purified Monoclonal Antibody
*The first user to submit a review for a product is eligible for Boster's Innovating Scientists Reward, which gives product credits. This is in addition to the gift card reward.
Customer Q&As
Have a question?
Find answers in Q&As, reviews.
Can't find your answer?
Submit your question
