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Product Info Summary
| SKU: | A02749 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-SCO2 Antibody
SKU/Catalog Number
A02749
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SCO2 Antibody (Catalog # A02749). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
SCO2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SCO2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02749)
Host
Rabbit
Contents
SCO2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SCO2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human SCO2. The immunogen is located within the last 50 amino acids of SCO2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of CLEC7A are known to exist.
Reactive Species
A02749 is reactive to SCO2 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
29810 MW
Background of SCO2
Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02749 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SCO2 antibody can be used for detection of SCO2 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SCO2 in HL60 cell lysate lysate with SCO2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of SCO2 in human liver tissue with SCO2 antibody at 2.5 μg/mL.
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Immunofluorescence of SCO2 in Human Liver tissue with SCO2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SCO2 (Source: Uniprot.org, NCBI)
Gene Name
SCO2
Full Name
Protein SCO2 homolog, mitochondrial
Weight
29810 MW
Superfamily
SCO1/2 family
Alternative Names
SCOD1, Protein SCO2 homolog, mitochondrial SCO2 CEMCOX1, ECGF1, Gliostatin, MC4DN2, MYP6, PD-ECGF, SCO1L, TP, TYMP, TdRPase synthesis of cytochrome C oxidase 2 protein SCO2 homolog, mitochondrial|Platelet-derived endothelial cell growth factor|SCO cytochrome c oxidase assembly protein 2|SCO cytochrome oxidase deficient homolog 2|SCO2, cytochrome c oxidase assembly protein|Thymidine phosphorylase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SCO2, check out the SCO2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SCO2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SCO2 Antibody (A02749)
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