SCO2 Antibodies

AND SCO2 ELISA kits, SCO2 Proteins

Many biological assays use antibodies to detect SCO2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCO2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCO2 antibodies...

We validate the specificity of these antibodies to SCO2 by testing them on tissues known to express SCO2 positively and negatively. Browse below to find the SCO2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SCO2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SCO2 Western Blot Guide

SCO2 Infographic by Boster Bio

All SCO2 Products

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Specificity

Applications

Price

Anti-SCO2 Antibody Picoband®

Western blot analysis of SCO2 using anti-SCO2 antibody (A02749-1)

Flow Cytometry analysis of PC-3 cells using anti-SCO2 antibody (A02749-1)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A02749-1
100 μg/vial

Anti-SCO2 Antibody

Western blot analysis of SCO2 in HL60 cell lysate lysate with SCO2 antibody at (A) 1 and (B) 2 μg/mL

Human

ELISA, IF, IHC-P, WB

$481
Cat # A02749
0.1 mg

SCO2 (NM_005138) Human Over-expression Lysate

SCO2 Human Over-expression Lysates NM_001169109

Human

$628
Cat # LS009997
20 µg, 100 µg

Human SCO2 Recombinant Protein

SDS-PAGE

$265
Cat # PROTO43819
Starting from 10ug

SCO2 Overview

Facts about Protein SCO2 homolog, mitochondrial.

SCO2 3D structure. Source: alphafold

Protein SCO2 homolog, mitochondrial (SCO2)

Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting aluminum to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203).

Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478). .

Gene Information

Human
Gene Name:	SCO2
Uniprot:	O43819
Entrez:	9997

Family

Belongs to:

SCO1/2 family

Alternative Names

cytochrome oxidase deficient homolog 2; MGC125823; MGC125825; protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2 (yeast); yeast) homolog 2

Molecular Weight

Mass (kDA):
29.81 kDA

Genomic Context


Human

Location:	22q13.33
Sequence:	22; NC_000022.11 (50523568..50526439, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Mitochondrion inner membrane; Single-pass membrane protein.

Diseases

Cytochrome-c Oxidase Deficiency
Cardiomyopathies
Hypertrophy
Hypertrophic Cardiomyopathy
Spindle Cell Oncocytoma Of The Adenohypophysis
Mitochondrial Diseases
Leigh Disease
Malignant Neoplasms
Neoplasms
Muscle Hypotonia
Encephalopathies
Atrophy

Myopathy
Acidosis
Muscular Atrophy
Copper Deficiency
Hypercapnia
Mitochondrial Encephalomyopathies
Acidosis, Lactic

Pathways

Transport
Oxidative Phosphorylation
Glycolysis
Aerobic Respiration
Cell Death
Electron Transport
Aging
Translation
Localization
Excretion
Response To Carbon Dioxide
Gene Silencing
Anaerobic Respiration

Cellular Homeostasis
Electron Transport Chain
Hypersensitivity
Cell Division
System Development
Cell Cycle
Seed Germination

PTMs

Phosphorylation
Reduction
Farnesylation

Glycosylation
Amidation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCO2

References

PMID: 10545952 by Papadopoulou L.C., et al. Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene.

PMID: 12529303 by Collins J.E., et al. Reevaluating human gene annotation: a second-generation analysis of chromosome 22.