Anti-SCYL1BP1 GORAB Antibody

Product Name

Anti-SCYL1BP1 GORAB Antibody

View all SCYL1BP1 Antibodies

SKU/Catalog Number

A09417

Size

100ul

Form

Liquid

Description

Boster Bio Anti-SCYL1BP1 GORAB Antibody catalog # A09417. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-SCYL1BP1 GORAB Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09417)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human SCYL1BP1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A09417 is reactive to GORAB in Human, Mouse, Rat

Applications

A09417 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

44.993kDa

Background of SCYL1BP1

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Devroe E., J. Biol. Chem. 279:24444-24451(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-1:2000
ELISA 1:20000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-SCYL1BP1 GORAB Antibody A09417

Western Blot (WB) analysis of AD293 cells using SCYL1BP1 polyclonal antibody.
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration

Gene/Protein Information For GORAB (Source: Uniprot.org, NCBI)

Alternative Names

FLJ11752; golgin, RAB6-interacting; GONTKL-binding protein 1; hNTKL-BP1; MGC51263; MGC70512; N-terminal kinase-like-binding protein 1; NTKL-BP1; NTKLBP1SCY1-like 1-binding protein 1; RAB6-interacting golgin; SCY1-like 1 binding protein 1; SCYL1-BP1; SCYL1BP1SCYL1-binding protein 1 GORAB GO, NTKLBP1, SCYL1BP1 golgin, RAB6 interacting RAB6-interacting golgin|N-terminal kinase-like-binding protein 1|NTKL-binding protein 1|SCY1-like 1-binding protein 1|SCYL1-binding protein 1

For more info on GORAB, check out the GORAB Infographic

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In this infographic, you will see the following information for GORAB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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