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- Table of Contents
PTPN11 Antibodies
AND PTPN11 ELISA kits, PTPN11 Proteins
Many biological assays use antibodies to detect PTPN11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN11 antibodies...
Designing a Western blot for PTPN11? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PTPN11 Western Blot GuideDesigning an IHC experiment for PTPN11? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PTPN11 IHC GuidePTPN11 Infographic by Boster Bio
All PTPN11 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00150-2
100 μg/vial
Cat # M00150-2
100 μg/vial
Anti-SHP2/PTPN11 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1860
100 μg/vial
Cat # PA1860
100 μg/vial
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00150-1
100 μl
Cat # M00150-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00150-5
20μL, 40μL, 100μL, 200μL
Cat # M00150-5
20μL, 40μL, 100μL, 200μL
Human, Mouse
IP, IF, ICC, WB
$370
Cat # P00150
100 μl
Cat # P00150
100 μl
Enzyme Activity, SDS-PAGE
$256
Cat # PROTQ06124-1
Starting from 10ug
Cat # PROTQ06124-1
Starting from 10ug
Human, Mouse, Rat
ELISA
$540
Cat # EKC1957
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1957
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1956
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1956
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1522
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1522
1 kit, containing one 96-well plate and all necessary reagents
PTPN11 Overview
Facts about Tyrosine-protein phosphatase non-receptor type 11.
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to take part in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573).
Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at'Tyr-722' resulting in stimulatation of its RhoA binding activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPN11 |
| Uniprot: | Q06124 |
| Entrez: | 5781 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
BPTP3; EC 3.1.3.48; MGC14433; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP1D; PTP-1D; PTP2C; PTP-2C; PTP2CNS1; PTPN11; SHP2; SHP-2; SHP2CFC; SHPTP2; SH-PTP2; SH-PTP2Noonan syndrome 1; SH-PTP3; tyrosine-protein phosphatase non-receptor type 11
Molecular Weight
Mass (kDA):
68.011 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.13 |
| Sequence: | 12; NC_000012.12 (112418915..112509918) |
Tissue Specificity
Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Noonan Syndrome
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Dwarfism
- Congenital Heart Defects
- Leopard Syndrome
- Myelomonocytic Leukemia
- Juvenile Myelomonocytic Leukemia
- Posttransfusion Purpura
- Hypertrophy
- Cardiomyopathies
Interacting Proteins
- AR
- CCKBR
- CD244
- CD33
- DDR1
- EGFR
- EPHA2
- ERBB2
- FLT1
- FRS2
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Activation
- Cell Growth
- Cell Adhesion
- Localization
- Cell Migration
- Secretion
- Cell Death
- Cell Cycle
- Cell Differentiation
- T Cell Activation
- Hypersensitivity
PTMs
- Phosphorylation
- Dephosphorylation
- Oxidation
- Glycosylation
- Methylation
- Cleavage
- Myristoylation
- Nitration
- Biotinylation
Research Areas
- Angiogenesis
- Cancer
- Cell Biology
- Lipid and Metabolism
- Phospho-Specific
- Signal Transduction
- Tyrosine Kinases
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN11
bosterbio.com/bosterbio-gene-info-cards/PTPN11
References
PMID: 1281790 by Adachi M., et al. Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.
PMID: 1280823 by Freeman R.M. Jr., et al. Identification of a human src homology 2-containing protein-tyrosine- phosphatase: a putative homolog of Drosophila corkscrew.