Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody

SHP-2/PTPN11 antibody

Boster Bio Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody catalog # M00150. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

Product Info Summary

SKU: M00150
Size: 100 μl
Reactive Species: Human
Host: Rabbit
Application: IP, IF, IHC, ICC, WB

Product Name

Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody

View all SHP-2/PTPN11 Antibodies

SKU/Catalog Number

M00150

Size

100 μl

Form

Liquid

Description

Boster Bio Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody catalog # M00150. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-SHP2 PTPN11 Rabbit Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00150)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Clonality

Monoclonal

Clone Number

GCA-16

Isotype

Rabbit IgG

Immunogen

A synthesized peptide derived from human SHP2

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Detects ~20kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.

Reactive Species

M00150 is reactive to PTPN11 in Human

Applications

M00150 is guaranteed for IP, IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

34 kDa

Calculated molecular weight

68.011kDa

Background of SHP-2/PTPN11

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns (4,5) P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:1000-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200
IP 1:50

Validation Images & Assay Conditions

Gene/Protein Information For PTPN11 (Source: Uniprot.org, NCBI)

Gene Name

PTPN11

Full Name

Tyrosine-protein phosphatase non-receptor type 11

Weight

68.011kDa

Superfamily

protein-tyrosine phosphatase family

Alternative Names

BPTP3; EC 3.1.3.48; MGC14433; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP1D; PTP-1D; PTP2C; PTP-2C; PTP2CNS1; PTPN11; SHP2; SHP-2; SHP2CFC; SHPTP2; SH-PTP2; SH-PTP2Noonan syndrome 1; SH-PTP3; tyrosine-protein phosphatase non-receptor type 11 PTPN11 BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 protein tyrosine phosphatase non-receptor type 11 tyrosine-protein phosphatase non-receptor type 11|SH2 domain-containing protein tyrosine phosphatase 2|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PTPN11, check out the PTPN11 Infographic

PTPN11 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PTPN11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M00150

100μL

$370
M00150-30ul

30μL sample

$99
M00150-carrier-free

Carrier Free

$370

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