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Product Info Summary
| SKU: | A04515 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-SIK2 Antibody
View all SNF1LK2/SIK2 Antibodies
SKU/Catalog Number
A04515
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SIK2 Antibody (Catalog # A04515). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SIK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SIK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04515)
Host
Rabbit
Contents
SIK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
SIK2 antibody was raised against a 16 amino acid synthetic peptide near the center of human SIK2. The immunogen is located within amino acids 270 - 320 of SIK2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SIK2 antibody is predicted to not cross-react with other SIK protein family members.
Reactive Species
A04515 is reactive to SIK2 in Human, Mouse, Rat
Applications
A04515 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
103.915kDa
Background of SNF1LK2/SIK2
Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SIK2 antibody can be used for detection of SIK2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 μg/mL.
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Immunocytochemistry of SIK2 in SW480 cells with SIK2 antibody at 2.5 μg/ml.
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Immunofluorescence of SIK2 in SW480 cells with SIK2 antibody at 5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For SIK2 (Source: Uniprot.org, NCBI)
Gene Name
SIK2
Full Name
Serine/threonine-protein kinase SIK2
Weight
103.915kDa
Superfamily
protein kinase superfamily
Alternative Names
DKFZp434K1115; EC 2.7.11; EC 2.7.11.1; KIAA0781SIK-2; LOH11CR1I; QIK; QIKSNF1LK2; Qin-induced kinase; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK2; SNF1-like kinase 2; SNF1LK2 SIK2 LOH11CR1I, QIK, SIK-2, SNF1LK2 salt inducible kinase 2 serine/threonine-protein kinase SIK2|SNF1-like kinase 2|qin-induced kinase|salt-inducible protein kinase 2|salt-inducible serine/threonine kinase 2|serine/threonine-protein kinase SNF1-like kinase 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SIK2, check out the SIK2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SIK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SIK2 Antibody (A04515)
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No publications found for A04515
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Customer Reviews
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