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- Table of Contents
SIK2 Antibodies
AND SIK2 ELISA kits, SIK2 Proteins
Many biological assays use antibodies to detect SIK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIK2 antibodies...
Designing a Western blot for SIK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SIK2 Western Blot GuideDesigning an IHC experiment for SIK2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SIK2 IHC GuideSIK2 Infographic by Boster Bio
All SIK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04515-1
100 μg/vial
Cat # A04515-1
100 μg/vial
SIK2 Overview
Facts about Serine/threonine-protein kinase SIK2.
Serine/threonine-protein kinase SIK2 (SIK2)
Phosphorylates'Ser-794' of IRS1 in insulin-stimulated adipocytes, possibly regulating the efficacy of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | SIK2 |
| Uniprot: | Q9H0K1 |
| Entrez: | 23235 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp434K1115; EC 2.7.11; EC 2.7.11.1; KIAA0781SIK-2; LOH11CR1I; QIK; QIKSNF1LK2; Qin-induced kinase; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK2; SNF1-like kinase 2; SNF1LK2
Molecular Weight
Mass (kDA):
103.915 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.1 |
| Sequence: | 11; NC_000011.10 (111602449..111730855) |
Subcellular Localizations
Cytoplasm.
Diseases
- Insulin Resistance
- Diabetes Mellitus
- Malignant Neoplasms
- Diabetes Mellitus, Non-insulin-dependent
- Melanoma
- Ischemia
- Obesity
- Inflammation
- Liver Diseases
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Nonalcoholic Fatty Liver Disease
Interacting Proteins
- CEP250
- GABARAPL2
- PIK3R1
Pathways
- Localization
- Glucose Homeostasis
- Gluconeogenesis
- Centrosome Separation
- Response To Camp
- Mitosis
- Cell Growth
- Pigmentation
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIK2
bosterbio.com/bosterbio-gene-info-cards/SIK2
References
PMID: 14976552 by Lizcano J.M., et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
PMID: 15454081 by Screaton R.A., et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.