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Product Info Summary
| SKU: | A01615 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Slug SNAI2 Antibody
SKU/Catalog Number
A01615
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Slug SNAI2 Antibody (Catalog # A01615). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
Slug antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Slug SNAI2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01615)
Host
Rabbit
Contents
Slug Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Slug antibody was raised against a 14 amino acid synthetic peptide from near the center of human Slug. The immunogen is located within amino acids 70 - 120 of Slug.
Reactive Species
A01615 is reactive to SNAI2 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
30.0 kDa
Background of SNAI2
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01615 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Slug antibody can be used for detection of Slug by Western blot at 1 to 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Slug in human kidney cell lysate with Slug antibody at in (A) 1 and (B) 2 μg/mL.
Specific Publications For Anti-Slug SNAI2 Antibody (A01615)
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