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Product Info Summary
| SKU: | M00274 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | WB |
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Product info
Product Name
Anti-SOCS3 Purified Monoclonal Antibody
SKU/Catalog Number
M00274
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SOCS3 Purified Monoclonal Antibody (Catalog# M00274). Tested in WB application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-SOCS3 Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00274)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
SO1
Isotype
Mouse IgG2b
Immunogen
Full-length SOCS3 protein. The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M00274 is reactive to SOCS3 in Human
Applications
M00274 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
24.77kDa
Background of SOCS-3
SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: Positive control: HeLa human cervix carcinoma cell line, reducing conditions.
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-SOCS3 Purified Monoclonal Antibody M00274
Western blotting analysis (reducing conditions) of whole cell lysate of HeLa human cervix carcinoma cell line.Lane 1: immunostaining with Isotype mouse IgG2b control (PLRV219; cat. no. 11-801-C100)
Lane 2: immunostaining with anti-SOCS3 (SO1)
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For SOCS3 (Source: Uniprot.org, NCBI)
Gene Name
SOCS3
Full Name
Suppressor of cytokine signaling 3
Weight
24.77kDa
Alternative Names
ATOD4; CIS3; CIS3CIS-3; Cish3; cytokine-induced SH2 protein 3; Cytokine-inducible SH2 protein 3; SOCS3; SOCS-3; SOCS-3STAT-induced STAT inhibitor 3; SSI-3; SSI-3ATOD4; SSI3MGC71791; suppressor of cytokine signaling 3 SOCS3 ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3 suppressor of cytokine signaling 3 suppressor of cytokine signaling 3|STAT-induced STAT inhibitor 3|cytokine-inducible SH2 protein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SOCS3, check out the SOCS3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SOCS3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SOCS3 Purified Monoclonal Antibody (M00274)
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No publications found for M00274
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