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Product Info Summary
| SKU: | A06722 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-SODD BAG4 Antibody
SKU/Catalog Number
A06722
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SODD BAG4 Antibody (Catalog # A06722). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SODD antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SODD BAG4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06722)
Host
Rabbit
Contents
SODD Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SODD antibody was raised against a peptide corresponding to amino acids near the amino terminus of human SODD. The immunogen is located within the first 50 amino acids of SODD.
Reactive Species
A06722 is reactive to BAG4 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
49.6 kDa
Background of BAG4
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06722 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SODD antibody can be used for detection of SODD by Western blot at 0.5 μg/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SODD in HeLa (1,3) and THP-1 (2,4) whole cell lysates in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. A06722P) with SODD antibody at 1:500 dilution.
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Immunocytochemistry of SODD in HeLa cells with SODD antibody at 5 μg/mL.
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Immunofluorescence of SODD in Hela cells with SODD antibody at 20 μg/mL.
Specific Publications For Anti-SODD BAG4 Antibody (A06722)
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