Anti-TAB3 Antibody

Product Name

Anti-TAB3 Antibody

View all NAP1 Antibodies

SKU/Catalog Number

A05084-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TAB3 Antibody (Catalog # A05084-1). Tested in ELISA, IHC-P applications. This antibody reacts with Human.

Storage & Handling

TAB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TAB3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05084-1)

Host

Rabbit

Contents

TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3. The immunogen is located within amino acids 40 - 90 of TAB3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.

Reactive Species

A05084-1 is reactive to Tab3 in Human

Applications

A05084-1 is guaranteed for ELISA, IHC-P Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

79.029kDa

Background of NAP1

TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 μg/mL.

Gene/Protein Information For Tab3 (Source: Uniprot.org, NCBI)

Alternative Names

CG5330; ; dNap; dNap1; dNAP-1; MAP3K7IP3; MGC45404; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NAP1; Nap-1; NF-kappa-B-activating protein 1; NFkB activating protein 1; p56/dCAF-4; TAB-3; TAK1-binding protein 3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3 Tab3|4921526G09Rik, Map3k, Map3k7ip3, mKIAA4135|TGF-beta activated kinase 1/MAP3K7 binding protein 3|TGF-beta-activated kinase 1 and MAP3K7-binding protein 3|TAK1-binding protein 3|TGF-beta-activated kinase 1-binding protein 3|mitogen-activated protein kinase kinase kinase 7-interacting protein 3

For more info on Tab3, check out the Tab3 Infographic

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In this infographic, you will see the following information for Tab3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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