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Product Info Summary
| SKU: | A11196 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Tectonic-2 TCTN2 Antibody
SKU/Catalog Number
A11196
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Tectonic-2 TCTN2 Antibody (Catalog # A11196). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
TCTN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Tectonic-2 TCTN2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11196)
Host
Rabbit
Contents
TCTN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TCTN2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCTN2. The immunogen is located within amino acids 610 - 660 of TCTN2.
Reactive Species
A11196 is reactive to TCTN2 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
76.9 kDa
Background of TCTN2
TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11196 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TCTN2 antibody can be used for detection of TCTN2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TCTN2 in SK-N-SH cell lysate with TCTN2 antibody at 1 μg/mL.
Specific Publications For Anti-Tectonic-2 TCTN2 Antibody (A11196)
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