Anti-TNF beta/LTA Antibody
Rabbit IgG polyclonal antibody for Lymphotoxin-alpha(LTA) detection. Tested with WB in Human.
Anti-TNF beta/LTA Antibody Info At A Glance
|Product Name||Anti-TNF beta/LTA Antibody
See all LTA primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TNF BETA/LTA detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. TNF BETA/LTA information: Molecular Weight: 22297 MW; Subcellular Localization: Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.|
|Cite This Product||Anti-TNF beta/LTA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1361)|
|Similar Products From
|Anti-TNF beta/LTA Antibody may replace the following items: sc 1352|sc 1353|sc 1354|sc 28345|sc 32767|sc 4565|sc 48410|sc 8302.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human TNF beta(73-88aa KQNSLLWRANTDRAFL), different from the related mouse sequence by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For LTA (Source: Uniprot.org, NCBI)
|NCBI Gene Id||4049|
|Species Of This Entry||Human|
|Superfamily||tumor necrosis factor family|
|Alternative Names||LTA|LT; LTA; LT-alpha; lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Lymphotoxinalpha; Lymphotoxin-alpha; tnfb; TNF-beta; TNFBlymphotoxin-alpha; TNFSF1; TNFSF1B; TNFSF1TNF-beta; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1|
|Post Tranlational Modifications||Phosphorylation; Glycosylation; Cleavage; Oxidation; Acylation; Ribosylation; Acetylation; Reduction; Methylation; Biotinylation; Deglycosylation; Hydroxylation; Nitration; Deacetylation; Nitrosylation; Carboxylation; Ubiquitination; Iodination|
|Subcellular Localization||Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.|
|Gene Location||6p21.33, on Chromasome 6, gene sequence: NC_000006.12 (31560550..31574324)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For LTA (Source: Uniprot.org, NCBI)
|Protein Function||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.|
|Related Diseases||Inflammation; Infective Disorder; Malignant Neoplasms; Inflammatory Response; Systemic Infection; Tissue Adhesions; Myocardial Infarction; Pneumonia; Infarction; Neoplasms; Bacterial Infections; Coronary Artery Disease; Asthma; Innate Immune Response; Carcinoma; Diabetes Mellitus; Septic Shock; Staphylococcal Infections; Dysequilibrium Syndrome; Hemorrhage|
|Related Pathways||Secretion; Pathogenesis; Immune Response; Platelet Aggregation; Inflammatory Response; Cytokine Production; Virulence; Localization; Innate Immune Response; Glycosylation; Coagulation; Autolysis; Transport; Cytokine Secretion; Hypersensitivity; Cell Division; Cell Activation; Macrophage Activation; Platelet Activation; Cell Death|
|Background||Lymphotoxin(previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Nedwin et al.(1985) found that TNFA and TNFB are closely linked on chromosome 6. Study of hybrid cells made with rearranged human chromosome 6 showed that both TNFA and TNFB map to the 6p23-q12 segment.|
|Scientific References||PMID: 3555974 by Nedospasov S.A., et al. Tandem arrangement of genes coding for tumor necrosis factor (TNF- alpha) and lymphotoxin (TNF-beta) in the human genome.|
PMID: 3001109 by Nedwin G.E., et al. Structure and chromosomal localization of the human lymphotoxin gene.
Our Boster Quality Guarantee for Anti-TNF beta/LTA Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Recombinant Human TNF beta Protein 10ng
Lane 2: Recombinant Human TNF beta Protein 5ng
Lane 3: Recombinant Human TNF beta Protein 2.5ng
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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