Anti-Transmembrane protein 18 TMEM18 Antibody

Product Name

Anti-Transmembrane protein 18 TMEM18 Antibody

View all TMEM18 Antibodies

SKU/Catalog Number

A05347

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Transmembrane protein 18 TMEM18 Antibody (Catalog # A05347). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

TMEM18 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Transmembrane protein 18 TMEM18 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05347)

Host

Rabbit

Contents

TMEM18 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TMEM18 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM18. The immunogen is located within the last 50 amino acids of TMEM18.

Reactive Species

A05347 is reactive to TMEM18 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

16.3 kDa

Background of TMEM18

Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A05347 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TMEM18 antibody can be used for detection of TMEM18 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information TMEM18

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