Anti-TREX2 Antibody

Product Name

Anti-TREX2 Antibody

View all TREX2 Antibodies

SKU/Catalog Number

A08960

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TREX2 Antibody (Catalog # A08960). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TREX2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08960)

Host

Rabbit

Contents

TREX2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TREX2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TREX2. The immunogen is located within the last 50 amino acids of TREX2.

Cross-reactivity

This TREX2 antibody will not cross-react with the related protein TREX1.

Reactive Species

A08960 is reactive to TREX2 in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

25.9 kDa

Background of TREX2

TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A08960 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TREX2 antibody can be used for detection of TREX2 by Western blot at 2.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information TREX2

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