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Product Info Summary
| SKU: | PA1992-1 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-TrkC/NTRK3 Antibody
SKU/Catalog Number
PA1992-1
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-TrkC/NTRK3 Antibody catalog # PA1992-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-TrkC/NTRK3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1992-1)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human TrkC, different from the related mouse and rat sequences by one amino acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1992-1 is reactive to NTRK3 in Human, Mouse, Rat
Applications
PA1992-1 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
85-91 kDa
Calculated molecular weight
94.428kDa
Background of TrkC
NTRK3 (Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al. (1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al. (1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain; in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al. (2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Validation Images & Assay Conditions
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Anti-TrkC antibody, PA1992-1, Western blotting
Lane 1: Rat Brain Tissue Lysate
Lane 2: Mouse Brain Tissue Lysate
Lane 3: U87 Cell Lysate
Lane 4: SHG Cell Lysate
Lane 5: NEURO Cell Lysate
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Anti-TrkC antibody, PA1992-1, IHC(P)
IHC(P): Human Mammary Cancer Tissue
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Anti-TrkC antibody, PA1992-1, IHC(P)
IHC(P): Rat Brain Tissue
Protein Target Info & Infographic
Gene/Protein Information For NTRK3 (Source: Uniprot.org, NCBI)
Gene Name
NTRK3
Full Name
NT-3 growth factor receptor
Weight
94.428kDa
Superfamily
protein kinase superfamily
Alternative Names
EC 2.7.10; EC 2.7.10.1; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT 3 receptor; NT-3 growth factor receptor; NTRK3; TrkC tyrosine kinase; TrkC; trk-C; TRKCneurotrophin 3 receptor; tyrosine kinase receptor C NTRK3 GP145-TrkC, TRKC, gp145(trkC) neurotrophic receptor tyrosine kinase 3 NT-3 growth factor receptor|ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|neurotrophic tyrosine kinase, receptor, type 3|tyrosine kinase receptor C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NTRK3, check out the NTRK3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NTRK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TrkC/NTRK3 Antibody (PA1992-1)
Hello CJ!
No publications found for PA1992-1
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Customer Reviews
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Customer Q&As
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1 Customer Q&As for Anti-TrkC/NTRK3 Antibody
Question
We are currently using anti-TrkC/NTRK3 antibody PA1992-1 for human tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on canine tissues as well?
Verified Customer
Verified customer
Asked: 2018-02-16
Answer
The anti-TrkC/NTRK3 antibody (PA1992-1) has not been validated for cross reactivity specifically with canine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2018-02-16
