Anti-TXNRD2 Antibody

Product Name

Anti-TXNRD2 Antibody

View all TXNRD2 Antibodies

SKU/Catalog Number

PA1903

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-TXNRD2 Antibody catalog # PA1903. Tested in IHC, WB applications. This antibody reacts with Human, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-TXNRD2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1903)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TXNRD2, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1903 is reactive to TXNRD2 in Human, Rat

Applications

PA1903 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

110 kDa

Calculated molecular weight

56.507kDa

Background of TXNRD2

TXNRD2 (Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are selenocysteine (sec)-containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing power of NADPH. By STS analysis and genomic sequence analysis, respectively, Miranda-Vizuete et al. (1999) and Sun et al. (1999) mapped the TXNRD2 gene to chromosome 22q11.2. Miranda-Vizuete et al. (1999) mapped the mouse gene to chromosome 16. Gasdaska et al. (1999) showed that TXNRD2 was a thioredoxin reductase that could directly reduce proteins such as insulin.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat

Validation Images & Assay Conditions

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Anti-TXNRD2 antibody, PA1903, Western blotting
Lane 1: Rat Kidney Tissue Lysate
Lane 2: Rat Ovary Tissue Lysate
Lane 3: Rat Liver Tissue Lysate
Lane 4: SMMC Cell Lysate

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Anti-TXNRD2 antibody, PA1903, IHC(P)
IHC(P): Human Lung Cancer Tissue

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Figure 3. IHC analysis of TXNRD2 using anti-TXNRD2 antibody (PA1903).
TXNRD2 was detected in paraffin-embedded section of rat intestine tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/ml rabbit anti-TXNRD2 Antibody (PA1903) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen.

Gene/Protein Information For TXNRD2 (Source: Uniprot.org, NCBI)

Alternative Names

EC 1.8.1; EC 1.8.1.9; KIAA1652; Selenoprotein Z; SelZ; Thioredoxin Reductase 2; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR; TR3; TR-beta; TRXR2; TRXR2thioredoxin reductase 2, mitochondrial; TXNRD2 TXNRD2 GCCD5, SELZ, TR, TR-BETA, TR3, TRXR2 thioredoxin reductase 2 thioredoxin reductase 2, mitochondrial|selenoprotein Z|thioredoxin reductase 3|thioredoxin reductase TR3|thioredoxin reductase beta

For more info on TXNRD2, check out the TXNRD2 Infographic

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In this infographic, you will see the following information for TXNRD2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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