Anti-TYK2(Ab-1054) Antibody

Product Name

Anti-TYK2(Ab-1054) Antibody

View all TYK2 Antibodies

SKU/Catalog Number

A01642

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-TYK2(Ab-1054) Antibody (Catalog # A01642). Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-TYK2(Ab-1054) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01642)

Host

Rabbit

Contents

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Peptide sequence around aa.1052~1056 (H-E-Y-Y-R) derived from Human TYK2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01642 is reactive to TYK2 in Human, Mouse, Rat

Applications

A01642 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

133.65kDa

Background of TYK2

TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Zheng H, et al. (2005) Mol Cell Proteomics. 4(6):721-730.
Gauzzi MC, et al. (1996) J Biol Chem. 271(34): 20494-20500.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Predicted MW: 140kd
Immunohistochemistry: 1:50~1:100

Validation Images & Assay Conditions

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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using TYK2(Ab-1054) antibody A01642(left) or the same antibody preincubated with blocking peptide(right).

Gene/Protein Information For TYK2 (Source: Uniprot.org, NCBI)

Alternative Names

EC 2.7.10; EC 2.7.10.2; JTK1; non-receptor tyrosine-protein kinase TYK2; Tyk2; tyrosine kinase 2 TYK2 IMD35, JTK1 tyrosine kinase 2 non-receptor tyrosine-protein kinase TYK2

For more info on TYK2, check out the TYK2 Infographic

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In this infographic, you will see the following information for TYK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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